...

REVEAL Neuronal microscopy for cell behavioural examination and manipulation

To achieve this goal, we will develop the necessary tools and the first instruments that will demonstrate the feasibility and the power of this new microscopy framework. In particular, we will develop a ‘cell picking neuronal microscope’ that will allow us to detect and collect different subtype of liver cells that are due to become tumoral and analyse them ahead of tumour manifestation. This analysis will help us to characterize the cellular heterogeneity known to exist at the origin of liver cancer. It will provide a direct mapping between cellular phenotypes observed under microscope and gene expression present in the early stages of liver cancer. Overall, we are thus defining a novel methodology, giving a central place to neuronal microscopy in the understanding of the cellular origin of the diseases.

REVEAL is a multidisciplinary project engaging 7 EU partners (2 being SMEs) from 4 countries covering the RTO, academic and industrial worlds, including medical doctors. An implementation plan is presented in the form of 6 work packages, 4 of them being technical. Synergy in communication and dissemination by the several partners and stakeholders will permit to maximize the project impact. Solutions to overcome the technological barriers, as well as appropriate deliverables, tasks, milestones and risks are presented, in order to complete the project objectives in due time. The REVEAL project outcomes are fully in line with the H2020 ICT-36-2020 call, subtopic iv, as it will develop novel methods and devices as research tools to understand the cellular origin of diseases.

 

Under Project REVEAL we will develop the necessary tools and the first instruments that will demonstrate the feasibility and the power of this novel microscopy framework. 

As a first test, we will target the cellular heterogeneity that lies at the origin of liver cancer. 

Once developed, the ‘cell-picking neuronal microscope’ will allow us to detect, identify and select pre-cancerous liver cells from a heterogenous mix and analyse them ahead of tumour manifestation. 

It will directly map cellular phenotypes observed under the microscope to gene and protein expression programs and cellular ultra-structures present in early stages of the disease. 

Overall, we are buliding an innovative and disruptive photonic tool,  which gives a central place to neuronal microscopy in the understanding of the cellular origin of the diseases.

video / video

partners / contact

CEA

[ CEA ]

France

Chiara PAVIOLO

Chiara PAVIOLO

IPRASENSE

[ IPRASENSE ]

France

Geoffrey ESTEBAN

Geoffrey ESTEBAN

ECOLE NORMALE SUPERIEURE DE LYON

[ ENS LYON ]

France

Kiran Padmanabhan

Kiran Padmanabhan

LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN

[ LMU ]

Germany

Maria ROBLES

Maria ROBLES

FONDAZIONE IRCCS CA' GRANDA OSPEDALE MAGGIORE POLICLINICO

[ PCLM ]

Italy

Luca VALENTI

Luca VALENTI

SARTORIUS AUTOMATED LAB SOLUTIONS GMB

[ SARTORIUS ]

Germany

Susanne FREYBERG

Susanne FREYBERG

POLITECHNIKA WARSZAWSKA

[ WUT ]

Poland

Wojciech KRAUZE

Wojciech KRAUZE

team / members

CEA IPRASENSE ENS LYON LMU PCLM SARTORIUS WUT

Maria BACZEWSKA

[ WUT ]

View bio

Sylvia DESISSAIRE

[ CEA ]

View bio

Geoffrey ESTEBAN

[ IPRASENSE ]

View bio

Susanne FREYBERG

[ SARTORIUS ]

View bio

Michał GONTARZ

[ WUT ]

View bio

Wojciech KRAUZE

[ WUT ]

View bio

Malgorzata KUJAWINSKA

[ WUT ]

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Arkadiusz KUŚ

[ WUT ]

View bio

graph - chart

Start 01/01/2021
85% 20/05/2024
End 31/12/2024
Budget allocation . M€ Budget allocation
Effort 634 p*m Effort
Effort 13 persons Full time equivalent

news

REVEAL Project Partners gathered in Warsaw fo...

2023-12-15

We’re thrilled to share some exciting updates from the recent REVEAL Project  General Assembly meeting held in Warsaw on the...

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POLITECHNIKA WARSZAWSKA (WUT) Presents REVEAL...

2023-12-02

Optic 2023 Conference, held in Tainan, Taiwan, on December 2nd, 2023, drew a gathering of approximately 250 attendees. Among...

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Epigenetics Meeting 24: A Resounding Success ...

2023-11-17

Epigenetics enthusiasts and scholars gathered in Grenoble for the Epigenetics Meeting 24 held on Thursday, November 17th,...

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ENS DE LYON Shines Light on REVEAL Project at...

2023-11-14

The departmental seminar hosted by CIRB, Collège de France, gathered 50 attendees in Paris, France, on November 14th, 2023....

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ENS DE LYON Illuminates REVEAL Project at Neu...

2023-11-10

The NeuroPSI departmental seminar, held in Paris, France, on November 10th, 2023, attracted an audience of 50 attendees. Among...

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ENS DE LYON Elevates REVEAL Project at the 15...

2023-11-09

The 15th Colloque des Belles Souris Symposium Seminar attracted a notable audience of 250 attendees on-site and 900...

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POLITECHNIKA WARSZAWSKA (WUT) Delivers Invite...

2023-10-22

The 6th Conference on Frontiers in Optical Imaging and Detecting Technology and Application attracted a significant audience...

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POLITECHNIKA WARSZAWSKA (WUT) Presents REVEAL...

2023-10-21

The seminar hosted by Nanjing University of Science and Technology attracted approximately 50 attendees to Nanjing, China, on...

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POLITECHNIKA WARSZAWSKA (WUT) Delivers Plenar...

2023-10-19

The VIII International Conference on Speckle Metrology brought together approximately 150 attendees in Xi'an, China, on...

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REVEAL presented at ICT36 online conference

2023-10-17

REVEAL project coordinator, Chiara Paviolo from CEA Leti, participated in online conference, where she presented our project....

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Martyna Mazur from POLITECHNIKA WARSZAWSKA (W...

2023-09-29

Martyna Mazur from WUT Engages at SFO Thematic School 2023: Waves in Complex Media

The SFO Thematic School 2023: Waves in...

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Poster presented at GRETSI conference

2023-09-26

Our colleague Florian Lemarchand from CEA-Leti participated in GRETSI conference, where he presented a poster related to his...

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PCLM Shares Insights on MASLD Pathophysiology...

2023-09-23

PCLM, representing the REVEAL project, took center stage at the EASL MASLD Summit in Prague on September 23, 2023, delivering...

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ENS DE LYON Spotlights REVEAL Project at Bioz...

2023-09-18

The Biozentrum departmental seminar convened 50 attendees in Basel, Switzerland, on September 18th, 2023. Among the...

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PCLM Delivers Forward-Thinking Presentation a...

2023-09-15

The European Association for the Study of Liver Disease (EASL) NAFLD Summit, convened in Dublin on September 15th, 2022,...

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POLITECHNIKA WARSZAWSKA (WUT) Presents REVEAL...

2023-09-12

The Polish Metrology Congress, a significant gathering of metrology professionals and researchers, convened approximately 110...

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POLITECHNIKA WARSZAWSKA (WUT) Showcases Deep ...

2023-08-09

The SPIE Optical Metrology Conference attracted approximately 100 attendees to Munich, Germany, on August 9th, 2023. Among the...

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PCLM Presents Groundbreaking Research at EASD...

2023-08-08

The 25th European Association for the Study of Diabetes (EASD) Oxford Workshop, themed "Diabetes: from the Liver to the...

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PCLM Delivers Invited Talk on Precision Medic...

2023-07-17

PCLM, representing the REVEAL project, contributed valuable insights to the seminar on "Metodi di Biocomputazione:...

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ENS LYON Presents Oral Presentation Promoting...

2023-07-13

ENS LYON, representing the REVEAL project, made a significant contribution to the IHIT Warsaw University departmental seminar...

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PCLM Delivers Invited Talk on Fatty Liver Dis...

2023-07-06

PCLM, representing the REVEAL project, delivered an impactful invited talk titled "A Functional Interaction Drives Fatty Liver...

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ENS DE LYON Presents REVEAL Project Insights ...

2023-07-05

The Departmental Seminar at CBI Toulouse witnessed a gathering of 70 esteemed attendees on July 5th, 2023, in Toulouse,...

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PCLM Shares Expertise on Genetic Cholestasis ...

2023-07-01

PCLM, representing the REVEAL project, contributed valuable insights to the webinar "Nuove Conoscenze sulle Colestasi...

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PCLM Presents Invited Webinar on MAFLD Defini...

2023-06-28

PCLM, representing the REVEAL project, delivered an invited webinar titled "Definizione, Epidemiologia e Stratificazione...

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PCLM's Participation in EASL Congress 2023: P...

2023-06-24

PCLM, representing the REVEAL project, played a dynamic role at the EASL Congress 2023 held in Wien, Austria, from June 21 to...

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PCLM Presents on Genetics in NAFLD at Bicocca...

2023-06-15

PCLM, representing the REVEAL project, delivered an invited talk titled "Genetics in NAFLD" at the Bicocca Hepato-Gastro...

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PCLM Delivers Invited Talk on NAFLD Risk Stra...

2023-05-25

PCLM, representing the REVEAL project, played a pivotal role at the "Integrated Management Approach for Cardiometabolic...

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Meet our new colleague - Alice Martin

2023-05-24

We would like to welcome onboard of REVEAL project our new team member. What Alice Martin has to say about herself?

I completed...

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PCLM Delivers Invited Talk on Epidemiology an...

2023-05-24

PCLM, representing the REVEAL project, made a significant contribution to the 91st Congress of the European Association of...

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ENS DE LYON Presents REVEAL Project Insights...

2023-05-23

NeuroFrance hosted a dynamic Translational Workshop on Sleep and Rhythms, attracting 100 enthusiastic attendees on May 23rd,...

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PCLM Presents Insights on Epidemiology and Ge...

2023-05-19

PCLM, representing the REVEAL project, delivered an oral presentation titled "Epidemiology and Genetics of Fatty Liver...

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LMU Commemorates 50 Years of the Max Planck I...

2023-04-25

The Max Planck Institute of Biochemistry celebrated a monumental milestone as it marked 50 years of groundbreaking research...

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PCLM Shares Insights on the Impact of Obesity...

2023-04-16

PCLM, representing the REVEAL project, delivered an invited talk at the Convegno SID Lombardia titled "Impatto di Obesità e...

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Celebrating 10 Years of IGFL at ENS LYON

2023-03-31

The IGFL at ENS LYON marked a significant milestone as it celebrated its 10-year anniversary with an international symposium...

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PCLM Delivers Invited Web-Talk on New Horizon...

2023-03-28

PCLM, representing the REVEAL project, was honored to deliver an invited web-talk at the "Obesity Dialogues: the...

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PCLM Presents on Genetics of Fatty Liver Dise...

2023-03-27

PCLM, representing the REVEAL project, made a contribution to the China Foreign Experts Program webinar held on March 27,...

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PCLM at 55th AISF Annual Meeting

2023-03-17

PCLM represented the REVEAL project at the 55th Annual Meeting of the Italian Association for the Study of the Liver (AISF)...

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ENS DE LYON Shines at LMU Munich CRC Consorti...

2023-03-09

The CRC Consortium for Chromatin Dynamics, hosted by LMU Munich, witnessed a gathering of 70 attendees on March 9th, 2023, in...

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POLITECHNIKA WARSZAWSKA Shines at IOS'2023 Co...

2023-03-02

The IOS'2023 Conference, dedicated to Integrated Optics-Sensors, Sensing Structures, and Methods, saw a gathering of...

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PCLM Engages in EASL Studio Webinar: "Genetic...

2023-02-22

PCLM recently took part in the EASL Studio Webinar titled "Genetics in Adult Liver Disease: Missed Opportunities?" held in...

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ENS DE LYON Elevates REVEAL Project at Indian...

2023-02-20

The Indian Institute of Science Education and Research in Trivandrum, India, hosted a dynamic seminar on February 20th, 2023,...

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Insightful Seminar at Indian Institute of Sci...

2023-02-17

The Indian Institute of Science Education and Research in Pune played host to a captivating seminar on February 17th, 2023,...

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PCLM Presents Groundbreaking Research on Geno...

2023-02-16

PCLM, representing the REVEAL project, made a significant impact at the 32nd Meeting of the Asian-Pacific Association for the...

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POLITECHNIKA WARSZAWSKA (WUT) Shines at SPIE...

2023-02-02

 POLITECHNIKA WARSZAWSKA (WUT) Shines at SPIE Photonics West: Showcasing Advancements in Quantitative Phase Imaging

The...

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PCLM Explores the Connection Between HCC and ...

2022-11-18

PCLM, representing the REVEAL project, delivered an oral presentation in Albano Laziale, Italy, on November 18, 2022. With a...

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ENS DE LYON Showcases REVEAL Project at Chrom...

2022-11-17

ENS DE LYON, representing the REVEAL project, made a significant impact at the Chromatin Symposium held in Grenoble, France,...

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Sleep and Chronobiology European School

2022-11-12

The Sleep and Chronobiology European School 2022 recently concluded in Munich, Germany, drawing approximately 40 enthusiastic...

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PCLM Explores NAFLD and Extra-Hepatic Maligna...

2022-10-29

PCLM, representing the REVEAL project, made significant contributions to the NAFLD Symposium at the Annual Congress of the...

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PCLM Chairs Seminar on Hyperferritinemic Synd...

2022-10-22

PCLM, representing the REVEAL project, played a pivotal role in the recent Annual Meeting of the Società Italiana di Medicina...

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PCLM Explores Heterogeneity of Fatty Liver Di...

2022-10-14

PCLM, representing the REVEAL project, took the virtual stage at the "Heterogeneity in Nutritional and Metabolic Health"...

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ISCTC, UniCaen, departmental seminar

2022-10-11

This month, ENS DE LYON promoted the REVEAL project at ISCTC, UniCaen, departmental seminar, in Caen, France.

ENS DE LYON Shines Light on REVEAL Project at...

2022-10-07

ENS DE LYON, representing the REVEAL project, played a pivotal role in the recent seminar hosted by the Chinese Society for...

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PCLM Presents NAFLD Summit Recap at Liver Cen...

2022-10-04

PCLM, representing the REVEAL project, recently took the virtual stage at the Liver Center Webinar held on October 4, 2022, to...

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CEA visits WUT in Warsaw

2022-09-23

Last week delegation of  CEA-Leti with Cédric Allier and Ondrej Mandula came to Warsaw to work with Warsaw University of...

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PCLM Shares Insights on Publishing in Liver I...

2022-09-21

On September 21st, 2022, amidst a virtual gathering of 50 attendees, the SCI Journal Writing Prestige Online Workshop provided...

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PCLM Delivers Insightful Talk at the European...

2022-09-21

The European Atherosclerosis Society (EAS) recently hosted a webinar on September 21, 2022. Among the participants was PCLM,...

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We seek a PhD student for the REVEAL project

2022-08-29

Warsaw University of Technology, one of REVEAL partners is looking for a PhD student to work on REVEAL project.

A 2-year funded...

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ENS DE LYON promoting REVEAL at EBRS (Europe...

2022-07-28

This month ENS DE  LYON promoted the REVEAL project at EBRS (European biological rhythms Society) Congress in Zurich,...

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Modified fibroblasts cells imaged and analyse...

2022-06-03

Heterogeneity in lung fibroblast cells in 2D culture REVEALed” analysed through CNNs. Experiment at IGFL ENS DE LYON, deep...

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ENS had offered to welcome a student from Ukraine

2022-05-17

The biology department of ENS will welcome Yevhenii Kostenko, a Ukrainian student, in the biosciences master's program at the...

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Reveal online training - video lensfree micro...

2022-03-31

Cedric Allier from CEA France organised an online training for Reveal project partners. He talked about video lensfree...

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Free online training with PhotonHub

2022-02-21

Reveal partners from Warsaw University of Technology were giving a an online training “Qulitative Phase Imaging at Cellular...

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A functioning silico visual cortex! - First s...

2022-01-28

The work conducted in the Reveal project has led to the achievement of the first milestone (under the responsibility of CEA)...

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Meet our new colleague - Marine Leprince

2022-01-24

We would like to welcome onboard of REVEAL project our new team member. 

„Hi, I am the new R&D optical enginner at IPRASENSE. I...

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Reveal online training - 2D and 3D phase imag...

2022-01-18

On 6th of December 2021 our partners from Warsaw University of Technology organised an online training for Reveal project...

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Meet our new colleague - Romain Ravaille

2022-01-04

We would like to welcome onboard of REVEAL project our new team member. 

„Hi! I’m Romain Ravaille, research engineer recently...

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Meet our new colleague - Florian Lemarchand

2021-12-21

We would like to welcome onboard of Reveal project our new team member Florian Lemarchand. He conducted his PhD in...

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Reveal trainings for project partners

2021-11-09

When you deal with matter as complex as we do in Reveal Project, training and constant learning is a must. That's why we are...

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Meet our new colleague - Sanket Nagarkar

2021-10-21

We would like to welcome onboard of Reveal project our new recruit and postdoctoral researcher Sanket Nagarkar, who joined...

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The Ludwig Maximilian University of Munich is...

2021-03-30

A three-year funded postdoc position is currently available in the laboratory of Maria Robles, Systems Chronobiology, at the...

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Kickoff Meeting

2021-01-21

The REVEAL project has officially started.

On the January 21st, 2021 REVEAL project's consortium met remotely to launch the...

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Launch of REVEAL project

2021-01-03

Launch of REVEAL, an innovative project aimed at imaging live cells in 2D and 3D by installing an innovative microscope at the...

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events

2022-06-12

Polish Optical Conference 2022

The Polish Optical Conference aims to integrate the community of Polish opticians and create a platform for meeting and exchanging views of a wide group of people for whom the development of Polish scientific and engineering thought as well as didactics in the field of optics is important. The conference combines a high scientific level with a possibly wide thematic spectrum so that it is representative of the entire Polish optics. Carefully selected invited lectures enable young scientists who start their work to learn about the subject of research conducted in other centers in the country.

2022-04-07

SPIE PHOTONICS EUROPE

SPIE Photonics Europe 2022 is a cross-disciplinary event highlighting compelling optics and photonics technologies—from digital optics to quantum technologies to optical imaging, sensing, and metrology.

2022-03-18

JIONC - Unconventional Optical Imaging Days

JIONC conference covering topics like:

  • Unconventional Imaging Modalities
  • Design of innovative imagers
  • Unconventional Imaging Treatment Methods
  • “Inverse problem” approaches for imaging
  • Biomedical imaging
  • Applications of these imaging systems

documents

OPEN-ACCESS SCIENTIFIC PUBLICATIONS

Cell culture analysis through learning-enabled lens-free microscopy

Circulating Interlukin-32 and Altered Blood Pressure Control in Individuals with Metabolic Dysfunction

CNN-Based Cell Analysis: From Image to Quantitative Representation

DetailedstratifiedGWASanalysisforsevereCOVID-19infourEuropeanpopulations

Estrogen–ER-α axis induces PNPLA3 p.I148Mprotein variant to promote steatotic liver disease susceptibility in women

Interaction between estrogen receptor-α and PNPLA3 p.I148M variant drives fatty liver disease susceptibility in women

Numerical refractive index correction for the stitching procedure in tomographic quantitative phase imaging

Phase unwrapping using deep learning in holographic tomography

Prevalence and Determinants of Liver Disease in Relatives of Italian Patients With Advanced MASLD

Roadmap on Digital Holography-Based Quantitative Phase Imaging

The genetics of portal hypertension: Recent developments and the road ahead

Towards true volumetric refractive index investigation in tomographic phase microscopy at the cellular level

Volumetric segmentation of biological cells and subcellular structures for optical diffraction

DELIVERABLES

REVEAL_ D5.1_310321_PU

REVEAL_D5.2_23072021_PU

REVEAL_D6.1_310321_PU

COMMUNICATION MATERIALS

Reveal Leaflet - for web

This project has received funding from the European Union’s Horizon Europe research and innovation programme under grant agreement No 101046084. This publication [communication] reflects the views only of the author, and the Commission cannot be held responsible for any use which may be made of the information contained therein.

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